Theaimof this study was to investigate possible associations between genetic polymorphisms of IL17A G197A(rs2275913) and IL17F\nT7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with\nchronic Chagas cardiomyopathy (CCC). The study with 260 patients and 150 controls was conducted in the South and Southeast\nregions of Brazil.Thegenotyping was performed by PCR-RFLP.The A allele and A/A genotype of IL17A were significantly increased\nin patients and their subgroups (patients with CCC; patients with CCC and LVSD; and patients with CCC and severe LVSD) when\ncompared to the control group. The analysis according to the gender showed that the A/A genotype of IL17A was more frequent\nin female with LVSD and mild to moderate LVSD and also in male patients with LVSD. The frequency of IL17F T/C genotype was\nhigher in male patients with CCC and severe LVSD and in female with mild to moderate LVSD. The results suggest the possible\ninvolvement of the polymorphisms of IL17A and IL17F in the susceptibility to chronic Chagas disease and in development and\nprogression of cardiomyopathy.
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